Antibacterial-enhanced Synthetic Stainless Steel, Hydroxyapatite, and Polylactic Acid in Bioactive Screw Systems for Safe Bone Healing

  • Eka Cahya Prima Department of Science Education, Faculty of Mathematics and Science Education, Universitas Pendidikan Indonesia, Bandung 40154, Indonesia
  • Putri Sekar Melati Department of Science Education, Faculty of Mathematics and Science Education, Universitas Pendidikan Indonesia, Bandung 40154, Indonesia
  • Fina Nurul Arifah Department of Science Education, Faculty of Mathematics and Science Education, Universitas Pendidikan Indonesia, Bandung 40154, Indonesia
  • Arifin Septiyanto Department of Science Education, Faculty of Tarbiyah and Teacher Training, Universitas Islam Negeri Sunan Ampel, Surabaya 60237, Indonesia
  • Arip Nurahman Department of Physics Education, Fakultas Ilmu Terapan Dan Sains, Institut Pendidikan Indonesia, Garut 44112, Indonesia
  • Aniek Setiya Budiatin Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia
  • Nendar Herdianto Research Centre For Advanced Materials, National Research And Innovation Agency (BRIN), South Tangerang 15314, Indonesia
DOI: https://doi.org/10.47076/jkpis.v8i2.368
Keywords: Antibacterial biomaterials, Bioxcrew, Bone fractures, Osteointegration, Polylactic acid–hydroxyapatite (PLA–HA)

Abstract

Bone fractures are rising worldwide due to aging populations and increased trauma, creating demand for implants that overcome infection, delayed healing, and poor osteointegration. Multifunctional biomaterials, especially PLA–HA Bioxcrew systems, offer integrated mechanical support with antibacterial, anti-inflammatory, and osteogenic functions while remaining biocompatible. Implant-associated infections driven by Staphylococcus aureus and Gram-negative bacteria persist because of biofilm formation and chronic inflammation. Bioxcrew advancements address these barriers through metal-ion doping, nanoscale surface engineering, and incorporation of antimicrobial agents into biodegradable polymer matrices, enabling controlled ion release, immune modulation, stem-cell recruitment, and improved bone regeneration. Stainless steel provides strength, hydroxyapatite enhances biological integration, and PLA enables safe degradation and localized drug delivery, making their hybridization ideal for next-generation implants. Using a narrative–integrative review of peer-reviewed literature from 2018 to 2025, this study synthesizes trends in antibacterial strategies and regenerative performance. Findings show that hybrid Bioxcrew platforms significantly reduce infection risk and enhance functional bone healing.

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Published
2025-10-18
How to Cite
Prima, E., Melati, P., Arifah, F., Septiyanto, A., Nurahman, A., Budiatin, A., & Herdianto, N. (2025). Antibacterial-enhanced Synthetic Stainless Steel, Hydroxyapatite, and Polylactic Acid in Bioactive Screw Systems for Safe Bone Healing. Jurnal Kajian Peradaban Islam, 8(2), 185-200. https://doi.org/https://doi.org/10.47076/jkpis.v8i2.368
Issue
Vol 8 No 2 (2025): Islamic Research
Section
Islamic Health System
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